SIGNATURE DRUG TOXICITIES

SIGNATURE DRUG TOXICITIES:

Agranulocytosis- Clozapine

Aplastic Anemia- Chloramphenicol,
NSAIDs,
Benzene

Atropine like Side Effects- Tricyclics

Cardiotoxicity- Doxorubicin,
Daunorubicin

Cartilage Damage in children- Fluoroquinolones (Ciprofloxacin & Norfloxacin)

Cinchonism- Quinidine

Cough- ACE Inhibitors

Diabetes Insipidus- Lithium

Disulfiram like effect- Metronidazole,
chlorpropamide,
cefoparazone

Extrapyramidal Side Effects- Antipsychotics (Thioridazine, Haloperidol, Chlorpromazine)

Fanconi's Syndrome- Tetracycline

Fatal Hepatotoxicity (necrosis)- Valproic Acid,
Halothane,
Acetaminophen

Gingical Hyperplasia- Phenytoin

Gray Baby Syndrome- Chloramphenicol

Gynecomastia- Cimetidine,
Azoles,
Spironolactone,
Digitalis,
Isoniazid

Hepatitis- Isoniazid

Hot Flashes, Flushing- Niacin,
Tamoxifen,
Ca ++ Channel Blockers

Induce CYP450- Barbiturates,
Phenytoin,
Carbamazepine,
Rifampin

Inhibit CP450- Cimetidine,
Ketoconazole

Interstitial Nephritis- Methicillin,
NSAIDs,
Furosemide,
Sulfonamides

Monday Disease- Nitroglycerin

Orange Body Fluids- Rifampin

Osteoporosis-
Heparin,
Corticosteroids

Positive Coombs' Test- Methyldopa

Pulmonary Fibrosis- Bleomycin,
Amiodarone

Red Man Syndrome- Vancomycin

SLE-like Syndrome- Procainamide,
Hydralazine

Tardive Dyskinesia- Antipsychotics (Thioridazine, Haloperidol, Chlorpromazine)

Tinnitus-
Quinidine

>>Plzz add other DRUG TOXICITIES to this list....!!!